Greg Martin. Medicine/Critical Care.
Phone: (404) 616-0148
Institution: Emory University
Location: Off-campus (but accessible via shuttle, e.g., Grady or VA Hospitals)
Lab Positions: 1
Project Description: Our group conducts clinical research involving patients in the intensive care units at Emory-affiliated hospitals, with the primary base of operations at Grady Memorial Hospital in Atlanta. Our research program encompasses a range of clinical trial designs from observational cohort studies to randomized controlled treatment trials. The disease focus is on sepsis (a life-threatening complication of infection) and acute respiratory distress syndrome (ARDS: a severe and life-threatening form of respiratory failure). Our interests lie in identifying factors that influence the occurence of these diseases, and may explain disparities in their occurence or outcome, and to identify optimal treatment strategies for these conditions. Undergraduate and graduate student participation in our group is dependent on training and skills, and could vary from screening and identification of eligible study subjects among hospitalized patients to management and/or mining of our registry database. Students will learn about the process and challenges of clinical research, including both regulatory and patient-specific issues, and about the conditions of interest for our group (primarily sepsis and ARDS).
Additional Project Information: We have conducted and continue to conduct projects involving hospital epidemiology and healthcare disparities, particularly as they focus on critical care conditions such as sepsis and acute respiratory distress syndrome (ARDS). See Martin GS, New England Journal of Medicine, 2003 as an example. Students will learn about the conditions of interest and about database manipulation, basic epidemiological principles and statistics.
Student Requirements: Understanding of human physiology is helpful as is previous experience working or volunteering in a medical environment.
Accepts 1st year students? Y
Accepts 2nd year students? Y
Suggested Reading (References):
(1) Martin GS, Mangialardi RJ, Wheeler AP, Dupont WD, Morris JA, Bernard GR. A randomized controlled clinical trial of albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med 2002; 30(10): 2175-82.
(2) Martin GS, Moss M, Wheeler AP, Mealer M, Morris JA, Bernard GR. A randomized controlled trial of furosemide with or without albumin in hypoproteinemic acute lung injury patients. Crit Care Med 2005; 33(8): 1681-87.
(3) Martin GS, Mannino DM, Eaton S, Moss M. The Epidemiology of Sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348(16): 1546-54.
(4) Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS. The Role of Infection and Co-Morbidity: Factors that Influence Disparities in Sepsis. Crit Care Med 2006; 34(10): 2576-82.
(5) Berkowitz DM, Danai PA, Eaton S, Moss M, Martin GS. Accurate characterization of extravascular lung water in acute respiratory distress syndrome. Crit Care Med 2008; 36(6): 1803-09.
Techniques used in this lab: See above, within the project descriptions.